Dissecting polycomb complexes for enhanced fetal hemoglobin production
Paul J. Kaminski, Kristen Min, Elizabeth A. Traxler, Eugene Khandros, Osheiza Y. Abdulmalik, Bailey N. Godfrey, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
This study uses CRISPR-Cas9 to identify EZH2 mutations that reactivate fetal hemoglobin without compromising cell fitness, showing potential for treating sickle cell disease and beta-thalassemia.
Blood · May 29, 2026Peer-reviewedMolecular Biology