Paul J. Kaminski

This study uses CRISPR-Cas9 to identify EZH2 mutations that reactivate fetal hemoglobin without compromising cell fitness, showing potential for treating sickle cell disease and beta-thalassemia.

This paper shows Top2 promotes HPV replication by inducing IL-6 and IL-8 secretion through TLR4, independent of DDR.

The paper identifies a p53-proteasome-LC3 axis that suppresses autophagy in DNA damaged cells, linking p53 stabilization to reduced LC3A/B levels.