Gerd A. Blobel

The paper identifies LDB1-dependent enhancer connectivity as critical for T-cell leukemia subtypes and reveals a metabolic vulnerability exploitable by statins.

This study uses CRISPR-Cas9 to identify EZH2 mutations that reactivate fetal hemoglobin without compromising cell fitness, showing potential for treating sickle cell disease and beta-thalassemia.

The paper uses Region Capture Micro-C to study microcompartment formation during mitosis-to-G1 transition, finding they form in prometaphase and are influenced by chromatin compaction and loop extrusion.

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

This study shows SSBP3 is essential for LDB1-mediated chromatin looping and transcription, and stabilizes LDB1 homodimers.

This study investigates how SMC complexes interact during mitosis to shape 3D genome structure by engineering cohesin/condensin configurations on mitotic chromosomes.

This study shows that most cis-regulatory element contacts and gene transcription after mitosis occur without loop extrusion, though some loops depend on NIPBL.

This study shows LDB1 directly promotes enhancer-promoter loops and organizes multi-enhancer networks to activate transcription, independent of CTCF, cohesin, or YY1.

This study identifies conserved and species-specific cis-regulatory elements in human and mouse blood cells using integrative epigenomic analysis and clustering.

The paper investigates how ZNF410 regulates the CHD4 gene through enhancer regions, showing additive contributions from two enhancers and cooperative binding of ZNF410 to clustered motifs.

This study investigates genome folding in condensin-depleted mitotic chromosomes, revealing compartmentalization mechanisms distinct from interphase.

The paper shows CTCF suppresses antisense transcription at divergent promoters without affecting sense transcription, using a combination of genetic and molecular techniques.

This study investigates how CTCF and transcription influence chromatin structure reconfiguration after mitosis, revealing their distinct roles in boundary formation and gene domain establishment.

This study investigates how chromatin shearing affects ChIP-seq quality and shows that sonication levels significantly impact signal quality and specificity for different transcription factors.

The paper identifies ZNF410 as a highly specific transcriptional activator in erythroid cells that regulates CHD4 and fetal hemoglobin expression.

The paper integrates epigenomic and transcriptomic data from mouse hematopoiesis to identify regulatory elements and their dynamics across cell types.

The paper examines 3D genome organization, epigenome, and transcriptome changes in fetal and adult mouse HSCs, finding stage-specific chromatin interactions and transcription factor roles.

The paper integrates GATA transcription factors and epigenomes in mouse hematopoietic cells using IDEAS to map regulatory landscapes and identify candidate cis-regulatory elements.

The paper examines how chromatin structures re-establish after mitosis using Hi-C, showing rapid compartment formation and dynamics of CTCF and cohesin binding.

The paper develops a framework to link Pol II ChIP-seq and single-cell data to transcriptional step rates, showing burst initiation and pause release are key regulated steps, while polymerase binding is not.

The paper identifies a causal variant near TMEM106B that alters chromatin architecture and gene expression, linking it to frontotemporal lobar degeneration and neurodegenerative disease risk.

The paper tracks Pol II occupancy genome-wide during mitosis-G1 transition and finds a transcriptional spike at the mitosis-G1 transition that exceeds later G1 levels.