Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model
Ming Tian, Jillian Davis, Hwei-Ling Cheng, Lily M Thompson, Marie-Elen Tuchel, Aimee M. Chapdelaine-Williams, Audrey Yin, Bailey Wilder, Ivy DiBiase, Michael S. Seaman, Frederick W. Alt
This paper develops a mouse model to study and overcome challenges in maturing HIV-1 broadly neutralizing antibodies by expressing a stalled VRC01 intermediate in germinal center B cells.
PLoS Pathogens · Jun 22, 2026Peer-reviewedImmunology