Receptor-guided engineering of oncolytic vaccinia creates a synthetic support niche for off-the-shelf NK cell therapy
Reza Rezaei, Zhiyang Gan, Ngomu Akeem Akilimali, Jordan Reff, Meiyin Lin, Yansen Xiao, Kush Parikh, Darsh Vithlani, Bakir Valentic, Alexander A Shestov, Ugur Uslu, Taha Azad, Roddy S OConnor, Carl H. June, Neil C. Sheppard
This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.
bioRxiv · Nov 9, 2026 · PreprintBioengineering