Neuropathological and Functional Impact of Astrocyte-Derived Extracellular Vesicles in an Aged Model of Alzheimer's Disease
Bao Quach, Sahar N Salehi, Rejina Roufegarinejad, Vishal Singh Guleria, Michael Mante, Jazmin B. Florio, Robert A. Rissman, Charisse N. Winston
This study shows that astrocyte-derived extracellular vesicles from cognitively impaired individuals promote tau accumulation in an Alzheimer's mouse model, suggesting they may be both biomarkers and drivers of neurodegeneration.
Experimental Neurology · Jul 3, 2026Peer-reviewedNeuroscience