This study shows that astrocyte-derived extracellular vesicles from cognitively impaired individuals promote tau accumulation in an Alzheimer's mouse model, suggesting they may be both biomarkers and drivers of neurodegeneration.

Experimental Neurology · Jul 3, 2026Peer-reviewedNeuroscience

Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview

AmanPreet Badhwar, Yael Hirschberg, Natalia Valle‐Tamayo, M. Florencia Iulita, Chinedu Theresa Udeh‐Momoh, Anna Matton, Rawan M. Tarawneh, Robert A. Rissman, Aurélie Ledreux, Charisse N. Winston, Arsalan S. Haqqani

The paper assesses BEV-enrichment protocols for blood biomarkers in neurodegenerative diseases and identifies CNS-specific proteins for enrichment and biomarker use.

Alzheimer s & Dementia · Jun 12, 2024Peer-reviewedNeuroscience

Evaluation of Blood-Based Exosomes as Biomarkers for Aging-Related TDP-43 pathology

Charisse N. Winston, Sonal Sukreet, Haley M. Lynch, Virginia M.‐Y. Lee, Donna M. Wilcock, Peter T. Nelson, Robert A. Rissman

This study evaluates blood-based exosomal TDP-43 as a biomarker for LATE-NC, finding elevated levels in ADEs from LATE-NC subjects but no correlation with cognition or APOE status.

bioRxiv · Jun 3, 2022 · PreprintNeuroscience