Loss of killifish cGAS/STING function attenuates cellular senescence and age-related signatures but does not extend organismal life span
Eugen Ballhysa, Roberto Ripa, Nadine Hochhard, Tin Tin Manh Nguyen, J. Tres Brazell, Baptiste Ferreri, Elena Hoffmann, Joachim David Steiner, Adam Antebi
This study shows that knocking out the cGAS/STING pathway in killifish reduces age-related cellular changes and inflammation but does not extend lifespan.
bioRxiv · Oct 8, 2024 · PreprintDevelopmental Biology