Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families
Pasquale C. Putter, Di Guan, Thies Gehrmann, Daniel Kolbe, Jiping Yang, HyeRim Han, Seungsoo Kim, Nico Lakenberg, H. Eka D. Suchiman, Stella Trompet, Georg C. Liu, Eugen Ballhysa, Adam Antebi, Niels van den Berg, Almut Nebel, , Joris Deelen
The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.
bioRxiv · Dec 9, 2025 · PreprintGenetics