Biologically grounded brain-on-chip model identifies selective topographic reorganization within hyperexcitable neural networks
Maxime Poinsot, Marine Dos Santos, Baptiste Marthy, Ana Borges-Correia, Eduardo Gascon, Benoît Charlot, Maxime Cazorla
The paper uses a brain-on-chip model to show genetic perturbations alter network topology in corticostriatal circuits, leading to new convergent nodes in hyperexcitable neural networks.
bioRxiv · Sep 30, 2024 · PreprintNeuroscience