Benoît Charlot

The paper tests asymmetric microchannel designs to promote unidirectional connectivity in cultured neuronal circuits and finds that the 'Rams' design achieves ~76% unidirectional connections and ~94% directional spiking activity.

The paper uses a brain-on-chip model to show genetic perturbations alter network topology in corticostriatal circuits, leading to new convergent nodes in hyperexcitable neural networks.