Molecular interplay between Integrative Mobile Elements exploiting Xer drives the evolution of cholera pandemics
Orlando Moranchel, Mael Balanec, Baptiste Verron, Lucie Royer, Christophe Possoz, Raphaël Guérois, Gilles Vergnaud, François‐Xavier Weill, James Iain Provan, François‐Xavier Barre
The paper investigates the integration order of IMEXs in V. cholerae, showing that TLC{Phi} and VGJ{Phi} encode Xer activators that facilitate CTX{Phi} integration, explaining the observed integration order in pandemic lineages.
bioRxiv · Jun 13, 2026 · PreprintMicrobiology