X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers
Esra Ayan, Miray Türk, Özge Tatlı, Sevginur Bostan, Elek Telek, Baran Dingiloğlu, B. Züleyha Doğan, Muhammed Ikbal Alp, Ahmet Katı, Gizem Dinler-Doğanay, Hasan Demirci
The paper uses X-ray crystallography and hydrogen-deuterium exchange to study insulin analog dynamics, showing faster deuterium exchange and structural insights into modified insulin monomers.
bioRxiv · Apr 16, 2024Biophysics