Esra Beyarslan Ayan

This study shows intranasal insulin does not reduce brain amyloid plaques in 5xFAD mice but changes intestinal morphology and fecal metaproteomics.

This paper introduces a novel Kapton-sealed Terasaki-plate method for powder X-ray diffraction that improves diffraction quality and reduces background compared to existing methods.

This study presents X-ray structures of detemir in hexameric and dodecameric forms, revealing structural dynamics and identifying key residues involved in conformational changes and stability.

The paper evaluates the Turkish Light Source diffractometer for small-molecule structure determination using three rhodanine derivatives, showing reliable results with some structural challenges.

This study reveals the pH-driven allosteric mechanism of hexamer glargine using serial femtosecond crystallography and multiscale analyses, showing a structural transition linked to delayed release.

This study compares structural heterogeneity of insulin analogs using crystallographic analysis across different temperatures, revealing analog-specific disorder patterns.

This study investigates how water and anion coordination affect insulin's structure and stability across a pH range, revealing pH-dependent electrostatic effects on protein dynamics and stabilization.

The paper examines temperature-induced structural changes in insulin, revealing dynamic shifts that impact thermal stability and provide insights for developing thermostable insulin formulations.

The paper uses X-ray crystallography and hydrogen-deuterium exchange to study insulin analog dynamics, showing faster deuterium exchange and structural insights into modified insulin monomers.

The paper evaluates mini-proinsulin analogs' structural and receptor binding dynamics to optimize recombinant insulin production in E. coli.

This study demonstrates a high-throughput drug screening protocol using serial femtosecond X-ray crystallography for SARS-CoV-2 main protease, achieving 120 images/second with a new detector.