Author

Muhammed İkbal Alp

Istanbul Medipol UniversityORCID 0000-0003-2075-7724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Ahmet KatıiD· 2 shared Emrah EroğluiD· 2 shared Esra Beyarslan AyaniD· 2 shared Sevginur BostaniD· 2 shared Alessia CedolaiD· 1 shared Arife Ahsen KaplaniD· 1 shared Asal Ghaffari ZakiiD· 1 shared Baran DingiloğluiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

Ahmet KatıORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT

Esra Beyarslan Ayan, Francesca Palermo, Giorgia Cavioli, Sevginur Bostan, Büşra Züleyha Doğan, Kader Kılıç, Arife Ahsen Kaplan, Inna Bukreeva, Lorenzo Massimi, Elena Longo, Gulsena Baydas, Ahmet Katı, Emrah Eroğlu, Gürkan Öztürk, Muhammed İkbal Alp, Alessia Cedola

This study shows intranasal insulin does not reduce brain amyloid plaques in 5xFAD mice but changes intestinal morphology and fecal metaproteomics.

bioRxiv · Oct 16, 2026 · PreprintBiophysics

Switching ON Hydrogen Sulfide: A Chemogenetic Toolkit for Spatially Resolved H2S Manipulation

Asal Ghaffari Zaki, Seyed Mohammad Miri, Emre Vatandaşlar, Sven Vilain, Esra Nur Yi̇ği̇t, Mehmet Şerif Aydın, Muhammed İkbal Alp, Emrah Eroğlu

This paper benchmarks two enzymes for controlled H2S production, finding that stDCyD generates only H2S while mDAAO also produces hydrogen peroxide.

bioRxiv · May 12, 2025 · PreprintBiochemistry

X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers

Esra Beyarslan Ayan, Miray Türk, Özge Tatlı, Sevginur Bostan, Elek Telek, Baran Dingiloğlu, Gizem Dinler Doğanay, Muhammed İkbal Alp, Ahmet Katı, Hasan DeMirci

The paper uses X-ray crystallography and hydrogen-deuterium exchange to study insulin analog dynamics, showing faster deuterium exchange and structural insights into modified insulin monomers.

PLoS ONE · Apr 21, 2025Peer-reviewedBiophysics