Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates
Benedetta Coppe, Prateek Arora, María Galardi‐Castilla, Andrés Sanz-Morejón, Theo Arthur Meister, Ksenia Skvortsova, Barbara Kupferschmid, Ayisha Marwa Mangattu Parambil, Nick Kirschke, Gianrico Gadient, Ines Joao Marques, Emrush Rexhaj, Ozren Bogdanović, Nadia Mercader
This study shows that paternal cardiac injury in vertebrates triggers inflammatory signals to the gonads, leading to intergenerational cardiac effects in offspring.
bioRxiv · Aug 24, 2026 · PreprintDevelopmental Biology