Mechanistic characterization of RASGRP1 variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibility
Julio E. Molineros, Bhupinder Singh, Chikashi C. Terao, Yukinori Okada, Jakub Kaplan, Barbara McDaniel, Shuji Akizuki, Celi Sun, Carol F. Webb, Loren L. Looger, Swapan K. Nath
The paper identifies a functional RASGRP1 variant associated with SLE risk through epigenetic and experimental validation, showing it regulates RASGRP1 expression via hnRNP-K binding.
Frontiers in Immunology · May 20, 2019Peer-reviewedGenetics