Author

Jakub Kaplan

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Andrew P. StoneiD· 1 shared Barbara McDaniel· 1 shared Bhupinder SinghiD· 1 shared Carol F. WebbiD· 1 shared Celi Sun· 1 shared Chikashi C. TeraoiD· 1 shared Clementine Payne· 1 shared Dong Hoon LeeiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Andrew P. StoneORCID

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2 papers

Recent·Most cited

Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production

Roelof Hendrik Bekendam, Virginia Camacho, Andrew P. Stone, María N. Barrachina, Siobhan Laken Branfield, Estelle Carminita, Isabelle C. Becker, Dong Hoon Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luís F.Z. Batista, Joseph E. Italiano, Kellie R. Machlus

The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.

bioRxiv · May 8, 2025 · PreprintCell Biology

Mechanistic characterization of RASGRP1 variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibility

Julio E. Molineros, Bhupinder Singh, Chikashi C. Terao, Yukinori Okada, Jakub Kaplan, Barbara McDaniel, Shuji Akizuki, Celi Sun, Carol F. Webb, Loren L. Looger, Swapan K. Nath

The paper identifies a functional RASGRP1 variant associated with SLE risk through epigenetic and experimental validation, showing it regulates RASGRP1 expression via hnRNP-K binding.

Frontiers in Immunology · May 20, 2019Peer-reviewedGenetics