DESI-MS-Based Analysis of Drug Distribution in Human Renal Cystic Tissue Using the Chorioallantoic Membrane (CAM) as a 3D In Vivo Model
Antonia Hehemann, Jan Schueler, Simon Heckscher, Verena Groß, Matthias May, Barbara Nuebel, Bernd Wullich, Bjoern Buchholz, Jens M. Werner, Jonathan Jantsch, Wolfram Gronwald, Zoltán Takáts, Peter Josef Oefner, Katharina Maria Schmidt, Silke Haerteis, Katja Dettmer
This study uses DESI-MSI to visualize benzbromarone distribution in human renal cyst tissue on the CAM model, showing selective accumulation at the cyst epithelium.
bioRxiv · Jul 1, 2026 · PreprintBiochemistry