Jonathan Jantsch

Machine learning-guided discovery of a conserved plasmid proteomic signature enables MALDI-TOF MS detection of pOXA-48-carrying Enterobacterales

The paper develops a machine learning model to detect pOXA-48-carrying Enterobacterales using MALDI-TOF MS spectra, achieving high accuracy across different cohorts.

DESI-MS-Based Analysis of Drug Distribution in Human Renal Cystic Tissue Using the Chorioallantoic Membrane (CAM) as a 3D In Vivo Model

This study uses DESI-MSI to visualize benzbromarone distribution in human renal cyst tissue on the CAM model, showing selective accumulation at the cyst epithelium.

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

The metabolic program of inflammatory eosinophils accounts for chronic parasite-induced skin-disease

This study shows that eosinophils contribute to chronic cutaneous leishmaniasis by expressing a unique metabolic profile that suppresses Th1 responses.