Silke Haerteis

DESI-MS-Based Analysis of Drug Distribution in Human Renal Cystic Tissue Using the Chorioallantoic Membrane (CAM) as a 3D In Vivo Model

This study uses DESI-MSI to visualize benzbromarone distribution in human renal cyst tissue on the CAM model, showing selective accumulation at the cyst epithelium.

Cyst-type epithelial heterogeneity shapes therapeutic responsiveness in ADPKD

The paper identifies three epithelial cyst types in ADPKD using single-nucleus RNA sequencing and machine learning, showing their association with therapeutic response.

Staphylococcus aureus triggers isolate-specific host transcriptional responses alongside TNF-R1 regulated cell death

This study shows that different S. aureus isolates trigger unique host transcriptional responses and cell death pathways, with TNF-R1 playing a key role in regulating infection outcomes in U937 cells.

Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation

This study identifies IL-33 as a key mediator in endometriosis pain and lesion formation through neuroimmune communication involving CGRP and macrophages.

High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins

This study uses blood vessel organoids to compare gene expression and cellular behavior in CCM1, CCM2, and CCM3 knockout models, revealing distinct functional roles that may explain differing disease severity.