AER-270 and TGN-020 are not aquaporin-4 water channel blockers
Lucas Unger, Kim Wagner, Jonas Hyld Steffen, Malene Lykke Wind, Tamim Al-Jubair, Hongjun Zou, Charlotte Clarke-Bland, Rebecca Murray, Bareerah Qureshi, Susanna L. Lundström, Massimiliano Gaetani, David R. Poyner, Hoor Ayub, Mark Wheatley, Pontus Emanuel Gourdon, , Philip Kitchen
This study shows that AER-270 and TGN-020 do not inhibit AQP4, contradicting their classification as AQP4 blockers and suggesting alternative mechanisms.
bioRxiv · Dec 4, 2024 · PreprintBiophysics