David R. Poyner

This paper introduces a series of BzAM terpolymers with varying hydrophobicity to solubilize GPCRs in nanodiscs, showing that solubilization efficiency and functional integrity are preserved.

This study compares the functional and structural properties of the intracellular agonist PCO371 with the extracellular peptide agonist PTH 1-34 at the PTH1R, revealing PCO371's non-biased signaling profile and lower potency.

This paper shows that sulfo-DIBMA nanodiscs preserve active-state signaling of class B1 GPCRs better than other copolymers, enabling functional studies of these receptors.

This study investigates how oxidative stress affects the structure, activity, and signaling of the Adenosine A2a Receptor (A2aR), finding no structural impact but increased cAMP levels in response to agonists under oxidative conditions.

This study shows that AER-270 and TGN-020 do not inhibit AQP4, contradicting their classification as AQP4 blockers and suggesting alternative mechanisms.