Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells
Detu Zhu, Zuxianglan Zhao, Guimei Cui, Shiehong Chang, Lingling Hu, Yi Xiang See, Michelle Gek Liang Lim, Dajiang Guo, Xin Chen, Barun Poudel, Paul Robson, Yumei Luo, Edwin Chong Wing Cheung
This study uses single-cell transcriptomics to show estrogen signaling enhances the mitochondrial folate pathway, supporting purine and polyamine synthesis in breast cancer cells.
Cell Reports · Nov 1, 2018Peer-reviewedGenomics