Paul Robson

The Genetic Discovery (GeDi) resource: Deep characterization of a multi-ancestry panel of human reference iPSCs for functional genomic studies

High-Resolution Spatial Transcriptomics Reveals Fibroblast and Neuroimmune Microenvironments in Endometriosis Lesions

This study uses high-resolution spatial transcriptomics to map fibroblast and neuroimmune microenvironments in endometriosis lesions, identifying spatial cellular interactions linked to pain.

STAR Suite: Transcriptomics processing in a single binary through AI-assisted development

Open-source STAR binary for five transcriptomic assays runs 3.9- to 6.2-fold faster than Cell Ranger 9.0.1 for scRNA-seq and Perturb-seq, 17- to 41-fold for Flex, with closely concordant counts.

Spatial organization of voltage-gated ion channel expression across molecularly defined neuronal populations in the mouse mammillary bodies

The paper maps the spatial distribution of voltage-gated ion channels in mouse mammillary bodies using FISH and links it to molecularly defined neuronal populations.

DIANNE: Segmentation-Free Localization of Histology Differential Attributes

DIANNE enables rapid training and inference of spatial differential attributes in histology images without manual annotations, using mixup augmentation and foundation models.

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

Prediction of Outcome from Spatial Protein Profiling of Triple-Negative Breast Cancers

The paper introduces SparTile, a computational method for analyzing multiplex proteomics images to identify clinically relevant spatial microenvironments in TNBC, finding specific markers and distances associated with poor survival.

spCorr: flexible and scalable inference of spatially varying correlation in spatial transcriptomics

spCorr identifies spatially varying gene correlations in spatial transcriptomics data, revealing biologically meaningful patterns and improving detection power while controlling FDR.

A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

Single-cell RNA sequencing reveals molecular features of postnatal maturation in the murine retinal pigment epithelium

The paper uses single-cell RNA sequencing to analyze RPE cell heterogeneity in mice, identifying six cell populations and changes in gene expression during maturation.

Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues.

This study uses single-cell transcriptomics to analyze endometriosis, identifying novel cell types and mechanisms in both eutopic and ectopic tissues.

Conserved cell-type specific signature of resilience to Alzheimer's disease nominates role for excitatory intratelencephalic cortical neurons

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

A Cellular Reference Resource for the Mouse Urinary Bladder

This paper defines the cellular composition of the mouse urinary bladder using single-cell profiling and spatial analysis, identifying novel cell types and fibroblast populations associated with aging.

Cellular taxonomy and spatial organization of the ventral posterior hypothalamus reveals neuroanatomical parcellation of the mammillary bodies

The paper uses scRNA-seq to classify cell types in the mouse ventral posterior hypothalamus, revealing distinct neuronal and non-neuronal populations and their spatial organization in the mammillary bodies.

Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells

This study uses single-cell transcriptomics to show estrogen signaling enhances the mitochondrial folate pathway, supporting purine and polyamine synthesis in breast cancer cells.

Dynamic changes in Sox2 spatio-temporal expression direct the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos

The paper quantifies Sox2 and Oct4 synergistic binding to Sox/Oct motifs, showing Sox2 levels drive Fgf4 expression, influencing cell fate decisions in mouse embryos.

Comprehensive Cell Type Specific Transcriptomics of the Human Kidney

This study profiles 22,469 human kidney cells to identify 27 cell types, novel markers, and interactions, highlighting endothelial cell roles in kidney disease.

CellView: Interactive Exploration Of High Dimensional Single Cell RNA-Seq Data

CellView provides an interactive web tool for exploring high-dimensional single cell RNA-seq data to enhance biological insights.