Yi Xiang See

Bambu-Clump improves transcript discovery and quantification from single-cell and spatial long-read RNA-seq data by leveraging cell and cluster information.

The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.

This study investigates how MYC overexpression affects chromatin interactions and c-Myc binding in cancer cells, revealing its role in stabilizing enhancer-promoter interactions and driving oncogene expression.

The paper identifies 'super-silencers' formed by chromatin interactions that regulate apoptotic genes and shows that combining GSK343 and X5050 disrupts these silencers to induce antitumor effects.

This study uses single-cell transcriptomics to show estrogen signaling enhances the mitochondrial folate pathway, supporting purine and polyamine synthesis in breast cancer cells.