CTCF-mediated cis-regulatory chromatin insulation enforces a central B-cell tolerance checkpoint
David Gomes, Eliraz Gitelman, Rena Levin-Klein, Anna Golberg, Ameen Haj-Yahia, Merav Hecht, Bar Avidov, Fernando Moises Castellani, Lamia Halaseh, Batia Azria, Arkadiy K. Golov, Natalia Tarnovitski Freund, Cornelis Murre, Noam Kaplan, Yotam Drier, Yehudit Bergman
This study identifies a CTCF-binding insulator element that regulates receptor editing and B-cell tolerance by controlling chromatin loop extrusion and Ig{lambda} development.
bioRxiv · Apr 14, 2026 · PreprintImmunology