Engineered micropillars to unveil oligodendrocyte responses to physical cues
Eva D. Carvalho, Miguel R. G. Morais, Helena P. Ferreira, Georgia Athanasopoulou, Hendrik Hubbe, Rui Rocha, M. Mattarelli, Beatriz Rocha Custódio, Sofia Assis, Shuyao Daniela Gu, Kashmyr A. Y. P. Dalang, Samuel Levi Rosemore, Wolfgang Losert, María Gómez-Lázaro, Silvia Caponi, , Ana Paula Pêgo
This paper develops a tissue-engineered model to study how physical cues like stiffness and axonal diameter affect oligodendrocyte myelination, finding that softer substrates promote differentiation while rigid ones maintain mature states.
bioRxiv · Mar 16, 2025 · PreprintBioengineering