Miguel R. G. Morais

Matrix stress-relaxation and stiffness modulate oligodendrocyte differentiation

This study shows that viscoelastic properties of 3D hydrogels impact oligodendrocyte differentiation and function, suggesting mechanotransduction as a target for remyelination therapies.

Engineered micropillars to unveil oligodendrocyte responses to physical cues

This paper develops a tissue-engineered model to study how physical cues like stiffness and axonal diameter affect oligodendrocyte myelination, finding that softer substrates promote differentiation while rigid ones maintain mature states.

Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination

This study identifies RhoA's role in regulating Schwann cell myelination by controlling cytoskeleton-membrane interactions and biomechanical responses.