Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in-vivo CAR-T therapy for inflamm-aging
Zihan Zhang, Bin Ma, Buyao Li, Zhiwei Li, Min Gao, Hailong Zhao, Rui Peng, Jiang‐Miao Hu, Yu Wang, Wei You, Xun Gui, Rui Wang, Xiaoqing Hu, Beidi Chen, Yuanjie Zhang, , Lei Miao
This study develops cardiolipin-mimic lipid nanoparticles for in vivo CAR-T therapy without antibody modification, treating liver fibrosis and rheumatoid arthritis via circular uPAR CAR mRNA.
Cell Reports Medicine · Jul 1, 2025Peer-reviewedBioengineering