Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface
Zeming Qiu, Wei Wang, Yingying Nie, Junxiang Lin, Beimeng Zhang, Haonan Xing, Sanduo Zheng
This study determines cryo-EM structures of GPR3 in active and inactive states, revealing dimerization mechanisms and identifying a negative allosteric modulator targeting the dimerization interface.
bioRxiv · Apr 19, 2025 · PreprintBiochemistry