Bidirectional allosteric ligand regulation in a central glycolytic enzyme
Belen Sundberg, Chenlin Lu, Malcolm L. Wells, Kyle C. Weber, Zhen Gong, Anum Azam Glasgow
This study resolves a long-standing discrepancy between the structural and functional properties of PFK by showing how activator and inhibitor binding differentially reweights its conformational ensemble.
Journal of the American Chemical Society · Aug 18, 2026Peer-reviewedBiophysics