Zhen Gong

This study resolves a long-standing discrepancy between the structural and functional properties of PFK by showing how activator and inhibitor binding differentially reweights its conformational ensemble.

The paper decodes energetic blueprints of conserved protein folds to explain functional diversity and enables engineered transcription factors with ligand-driven responses.

This paper identifies a small molecule inhibitor of PPARγ acetylation that improves insulin sensitivity and browning of white adipose tissue without the side effects of traditional PPARγ agonists.

The paper presents the cryo-EM structure of a nematode LGR dimer, providing insights into the evolution and function of glycoprotein hormone receptors.

The paper determines the structure of a plant-virus xrRNA and shows it forms a pseudoknot that confers exoribonuclease resistance, revealing a conserved mechanism across diverse viruses.