TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signalling
Carlos Matellan, Bella Raphael, Gareth‐Rhys Jones, Mary Nwaeziegwe, Sarah Balfe, Cian M. Ohlendieck, C Bauset, Méabh B. Ní Chathail, Ciarán Kennedy, Katie L. Doogan, Des C Winter, Carol M. Aherne, Helen M. Roche, Calum C. Bain, Stephen D. Thorpe, , Mario C. Manresa
This study shows TWEAK increases in ulcerative colitis and promotes monocyte activation through non-canonical NF-kB/STAT3 signaling in fibroblasts.
Journal of Crohn s and Colitis · Jan 31, 2026Peer-reviewedImmunology