Author

Carol M. Aherne

University College DublinORCID 0000-0001-5653-9003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Colm B. CollinsiD· 2 shared Hannah M Phelan· 2 shared Robert S. LeddyiD· 2 shared Bella Raphael· 1 shared Billy P Egan· 1 shared Brent E. PalmeriD· 1 shared C BausetiD· 1 shared Calum C. BainiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

Colm B. CollinsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cannabinoid CB2 receptor activation drives glucose uptake, shifting T cell metabolism.

Robert S. Leddy, Hannah M Phelan, Claire Connolly, Fabian Wehrmann, D Winter, Lorraine Brennan, David J O’Connell, Carol M. Aherne, Colm B. Collins

This paper shows that CB2R activation in T cells increases glucose uptake and shifts metabolism toward oxidative phosphorylation and the pentose phosphate pathway, with effects dependent on the receptor.

bioRxiv · Jul 10, 2026 · PreprintImmunology

Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs

Marika Orlov, Mallory Karr, Naoko Hara, James C. Needell, Carol M. Aherne, Jennifer L. Matsuda, Brent E. Palmer, Catherine Lozupone, S E Clark, William J. Janssen, Christopher M. Evans

This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.

bioRxiv · Mar 9, 2026 · PreprintImmunology

TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signalling

Carlos Matellan, Bella Raphael, Gareth‐Rhys Jones, Mary Nwaeziegwe, Sarah Balfe, Cian M. Ohlendieck, C Bauset, Méabh B. Ní Chathail, Ciarán Kennedy, Katie L. Doogan, Des C Winter, Carol M. Aherne, Helen M. Roche, Calum C. Bain, Stephen D. Thorpe, , Mario C. Manresa

This study shows TWEAK increases in ulcerative colitis and promotes monocyte activation through non-canonical NF-kB/STAT3 signaling in fibroblasts.

Journal of Crohn s and Colitis · Jan 31, 2026Peer-reviewedImmunology

Cannabinoid CB2R regulates T cell gut-homing in preclinical Crohns model.

Robert S. Leddy, Cinthia L. Hudachek, Hannah M Phelan, Billy P Egan, Carol M. Aherne, Julián Romero, Cece Hillard, Paul Jedlicka, Colm B. Collins

This study shows that CB2R signaling promotes T cell gut-homing in a preclinical Crohn's model by enhancing integrin 4β7 expression and transmigration across gut endothelial barriers.

bioRxiv · Sep 5, 2025 · PreprintImmunology