Author

Ben C. Shirley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Peter K. RoganiD· 5 shared Eliseos J. MucakiiD· 4 shared Joan H.M. KnolliD· 2 shared Elizabeth A. AinsburyiD· 1 shared Farrah Norton· 1 shared Jayne MoquetiD· 1 shared Ngoc-Duy Pham· 1 shared Ruth C. WilkinsiD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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5 shared papersGenomics

Peter K. RoganORCID

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Author profile →

5 papers

Recent·Most cited

Radiation Exposure Determination in a Secure, Cloud-based Online Environment

Ben C. Shirley, Eliseos J. Mucaki, Joan H.M. Knoll, Peter K. Rogan

This paper describes ADCI Online, a secure cloud-based platform for radiation dose estimation using dicentric chromosome assays, achieving results comparable to local systems in under 2 days.

Radiation Protection Dosimetry · Nov 23, 2022Peer-reviewedBioinformatics

Improved radiation expression profiling in blood by sequential application of sensitive and specific gene signatures

Eliseos J. Mucaki, Ben C. Shirley, Peter K. Rogan

The paper improves radiation exposure detection in blood by addressing confounding factors through enhanced gene signatures.

International Journal of Radiation Biology · Oct 26, 2021Peer-reviewedSystems Biology

Estimating partial body ionizing radiation exposure by automated cytogenetic biodosimetry

Ben C. Shirley, Joan H.M. Knoll, Jayne Moquet, Elizabeth A. Ainsbury, Ngoc-Duy Pham, Farrah Norton, Ruth C. Wilkins, Peter K. Rogan

This paper improves automated cytogenetic biodosimetry by correcting false positive dicentric chromosomes to estimate partial body radiation exposure.

International Journal of Radiation Biology · Sep 10, 2020Peer-reviewedGenetics

Expression changes confirm genomic variants predicted to result in allele-specific, alternative mRNA splicing

Eliseos J. Mucaki, Ben C. Shirley, Peter K. Rogan

The paper confirms that genomic variants predicted to affect alternative mRNA splicing indeed alter splice site strength and exon inclusion, using RNAseq and q-RT-PCR in HapMap and tumor datasets.

Frontiers in Genetics · Mar 5, 2020Peer-reviewedGenomics

Pan-Cancer Repository of Validated Natural and Cryptic mRNA Splicing Mutations

Ben C. Shirley, Eliseos J. Mucaki, Peter K. Rogan

The paper presents a validated pan-cancer repository of mRNA splicing mutations, identifying and characterizing over 350,000 mutations across multiple tumor types.

F1000Research · Dec 7, 2018Peer-reviewedGenomics