Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens
Fay J. Dufort, Christopher J. Leitheiser, Alexandra Rezvaya, Tucker Ezell, Kathleen Q.W. Ho, G.A. Bezerra, Ben J. F. Blakeman, Sandra Uhlenbroich, William H. Zammit, Lukas Stanczuk, Peter de Nully Brown, Gemma Mudd, Kevin A. McDonnell, Nicholas Keen, Philip E. Brandish
This paper develops synthetic peptides that activate NK cells to kill tumor cells by binding to NKp46 and tumor antigens, leading to cytokine secretion and enhanced anti-tumor immunity.
bioRxiv · Oct 30, 2024 · PreprintCancer Biology