Kevin A. McDonnell

How to design 1000-plex mass tags using the differential mass defect

This paper explores designing high-plex mass tags using differential mass defect to enable large-scale multiplexing in proteomics.

JMod: Joint modeling of mass spectra for empowering multiplexed DIA proteomics

JMod improves sequence identification and quantification in multiplexed DIA proteomics by jointly modeling overlapping mass spectra, enabling higher throughput with maintained accuracy.

timePlex: Increasing mass spectrometry throughput using time-encoded sample multiplexing

timePlex increases LC-MS throughput by multiplexing samples in the time domain, achieving combinatorial scaling and enabling high-throughput proteomics.

PSMtags improve peptide sequencing and throughput in sensitive proteomics

PSMtags enhance peptide detection and sequence identification in proteomics, enabling 9-plexDIA and significantly increasing sample throughput.

Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens

This paper develops synthetic peptides that activate NK cells to kill tumor cells by binding to NKp46 and tumor antigens, leading to cytokine secretion and enhanced anti-tumor immunity.