A mutation-resolved therapeutic atlas of NRAS-mutant melanoma reveals genotype-selective response to RAS(ON) inhibition and adaptive STAT3 survival
Sai Fung Yeung, July Xi Chen, Cherie Tsz‐Yiu Law, Alex Chun Ho Law, Carol Lee, Allen Ming Fai Leung, Mary Po Ki Chau, Ben Ko Chi-Bun, Wu Yue, Man Tong, 梁开喜, William C. Cho, Michelle K.Y. Siu, Karen Kar Loen Chan, Chunning Leung, Stephen Kwok‐Wing Tsui
This paper identifies genotype-specific responses to RAS(ON) inhibitors in NRAS-mutant melanoma and shows that STAT3 inhibition enhances therapeutic efficacy.
bioRxiv · Mar 13, 2026 · PreprintCancer Biology