Stephen Kwok‐Wing Tsui

Overcoming artificial structures in resolution-enhanced Hi-C data by signal decomposition and multi-scale attention

This paper introduces SHARP, a method to enhance Hi-C data resolution while avoiding artificial structures by decomposing signals and using multi-scale attention.

Can Large Language Models ''Read'' Biological Sequences? A Systematic Evaluation of In-Context Learning for Antibody Characterization

This study evaluates how large language models perform in-class learning for antibody classification using biological sequences, finding that few-shot prompting with diverse demonstrations achieves competitive results.

Precursor of chemically expanded hepatocytes (pre-cHep) with 1-million-fold expansion potential and liver repopulation capacity

The paper reports a method to reprogram primary human hepatocytes into proliferative pre-cHep cells with high expansion potential and liver repopulation capacity, offering an alternative to PHHs for drug testing and disease modeling.

nELAVL phosphorylation by CDKL5 regulates RNA metabolism and condensates communication to promote experience-dependent maturation of the visual cortex

This study identifies CDKL5-mediated phosphorylation of nELAVL as critical for regulating RNA metabolism and condensate communication, essential for visual cortex maturation.

A mutation-resolved therapeutic atlas of NRAS-mutant melanoma reveals genotype-selective response to RAS(ON) inhibition and adaptive STAT3 survival

This paper identifies genotype-specific responses to RAS(ON) inhibitors in NRAS-mutant melanoma and shows that STAT3 inhibition enhances therapeutic efficacy.

Functional and sensitivity profiling of theKITMutation Landscape in Melanoma

This study identifies KIT mutation hotspots in Asian melanoma and evaluates drug sensitivities, showing that some mutations are resistant to imatinib but responsive to other inhibitors.

Commonly used software tools produce conflicting and overly-optimistic AUPRC values

The paper evaluates 10 software tools for computing AUPRC and finds they produce conflicting and overly-optimistic results.

Sequencing of Panax notoginseng genome reveals genes involved in disease resistance and ginsenoside biosynthesis

The paper reports the first de novo genome of Panax notoginseng, identifies gene family contractions and expansions related to disease resistance and ABC transporters, and maps key genes in the ginsenoside biosynthesis pathway.

SSEalign: accurate function prediction of bacterial unannotated protein, based on effective training dataset

SSEalign improves function prediction of bacterial unannotated proteins using a training dataset from 20 bacterial genomes, achieving 91.2% test accuracy and annotating 99 of 149 unannotated proteins in JCVI-syn3.0.

Systematic selection of reference genes for normalization of circulating RNA transcripts in pregnant women based on RNA-seq data

The paper identifies a panel of stably expressed genes for normalizing circulating RNA transcripts in maternal blood using RNA-seq data from preterm labor samples.