FAP-intrinsic Hedgehog signaling controls intramuscular adipogenesis, fibrosis, and myofiber regeneration
Xinyue Liu, Vincent He, Benedict Deepesh, Alessandra Norris, Daniel Kopinke
This study shows that FAPs are the primary cells responding to Hedgehog signaling during muscle regeneration, and their signaling competence is critical for preventing adipogenesis, fibrosis, and promoting myofiber repair.
bioRxiv · Jun 2, 2026 · PreprintDevelopmental Biology