Daniel Kopinke

This study shows that autocrine IGF-I is essential for FAP function in muscle homeostasis and regeneration, with loss of IGF-I leading to impaired regeneration and altered FAP properties.

This study shows that semaglutide increases intramuscular fat formation and inhibits muscle fiber growth after injury, suggesting potential adverse effects on muscle regeneration.

This study shows that primary cilia in cardiac fibroblasts promote fibrosis and impair heart function after myocardial infarction by amplifying fibrotic signaling.

This study shows that FAPs are the primary cells responding to Hedgehog signaling during muscle regeneration, and their signaling competence is critical for preventing adipogenesis, fibrosis, and promoting myofiber repair.

This study shows that intramuscular adipose tissue (IMAT) accumulation worsens limb function in PAD/CLTI, and reducing IMAT improves muscle strength and work output in mice.

This study shows that blocking intramuscular adipose tissue (IMAT) formation after muscle injury improves muscle regeneration and function in mice.

This study identifies DHH as a key ligand in the Hedgehog signaling pathway that regulates fibro/adipogenic progenitor fate during skeletal muscle regeneration, preventing adipogenesis and promoting fibrosis.

This paper describes a protocol for preserving adipocyte morphology in skeletal muscle sections to study intramuscular fat formation and its cellular origin.

The paper applies Cellpose and a new ImageJ plugin to automatically and accurately segment myofibers in murine skeletal muscle, enabling unbiased quantification across different staining and fixation conditions.