PD-L1-linked spatial decoupling of tumour-immune interactions in EBV-positive DLBCL
Axel Künstner, Matthias Kümmel, Anke Fähnrich, Stefanie Derer, Annika Raschdorf, Hanno Maximilian Witte, Yamil Maluje, Benedikt Faerber, Thies Rösner, Lisa Michelson, Friederike Stiller, Mona Maria Merz, Veronica Bernard, Stephanie Stoelting, Daniel Kolbe, , Niklas Gebauer
The paper investigates how PD-L1 genomic gains in EBV-positive DLBCL alter spatial tumour-immune interactions, revealing immune evasion through fibroblast exclusion, metabolic suppression, and T-cell exhaustion.
medRxiv · Jul 4, 2026 · PreprintGenetic & Genomic Medicine