Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases
Julia Diecker, Benedikt Hermanns, Jennifer Rüschenbaum, René Rasche, Wolfgang Dörner, Alexander Schröder, Daniel Kümmel, Henning D. Mootz
The paper presents the first crystal structure of a cis-COM domain in NRPSs and shows its role in scaffolding domain architecture for efficient peptide synthesis.
Angewandte Chemie International Edition · Jul 8, 2025Peer-reviewedBiochemistry