Daniel Kümmel

This study identifies TANGO1 as a selective ECM cargo receptor that directly recognizes specific collagen and fibrillin isoforms through a conserved tyrosine residue, independent of HSP47.

This study reports the structure of the TSC complex catalytic transition state complex with Rheb, revealing the mechanism of TSCC's GAP activity and the role of TSC1 in conformational coupling.

This study identifies GAPsec as a novel Rab5 GAP required for endosomal maturation in fruit fly nephrocytes, showing its role in endosome-lysosome fusion.

The paper identifies Ldm1 and Ldo16 as actin-dependent lipid droplet motility mediators in yeast, showing their roles in LD movement and mitochondrial transport.

This study presents the cryo-EM structure of the RalGAP tumor suppressor complex, revealing its tetrameric architecture and providing insights into its function and relevance in cancer.

The paper presents the first crystal structure of a cis-COM domain in NRPSs and shows its role in scaffolding domain architecture for efficient peptide synthesis.

This study compares the structural and functional mechanisms of Mon1-Ccz1 and Fuzzy-Inturned RabGEFs to explain their target specificity and membrane recruitment.

The paper identifies aggregation as the cause of low splicing efficiency in a cysteine-less split intein and presents a rationally engineered variant with high activity.