Author

Benjamin B. Larsen

Princeton University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1

Frequent Co-Authors

Aartjan J.W. te VelthuisiD· 2 shared Cameron MyhrvoldiD· 2 shared Ofer KimchiiD· 2 shared Emily Gibson· 1 shared Owen R. S. DunkleyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

Aartjan J.W. te VelthuisORCID

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2 papers

Recent·Most cited

Intersegmental transfers drive target search in an RNA-targeting CRISPR system

Ofer Kimchi, Benjamin B. Larsen, Emily Gibson, Aartjan J.W. te Velthuis, Cameron Myhrvold

This study shows that Cas13 uses intersegmental transfers to efficiently search for RNA targets, differing from DNA-binding proteins.

bioRxiv · Jun 18, 2026 · PreprintBiophysics

RNA structure modulates Cas13 activity and enables mismatch detection

Ofer Kimchi, Benjamin B. Larsen, Owen R. S. Dunkley, Aartjan J.W. te Velthuis, Cameron Myhrvold

This study investigates how RNA structure affects Cas13 activity, revealing two mechanisms by which secondary structure modulates Cas13 and improving RNA detection through strand displacement.

Biophysical Journal · Feb 1, 2024Peer-reviewedMolecular Biology