High-throughput screen identifies a potent MCU activator boosting cardiac contractile bioenergetics
Elena Caldero-Escudero, Marilén Federico, Ángel Sánchez-González, Adrià Gil, Silvia Fernandez‐Martinez, Paloma García-Casas, Rosalba I. Fonteríz, Flavien Bermont, Benjamin Brinon, Silvia Romero-Sanz, Andrea Moran-Cerro, Luis González-Moreno, Araceli del Arco, Shey‐Shing Sheu, Jérôme N. Feige, , Jaime Santo Domingo
The paper identifies CGP7930 as a potent MCU activator that enhances cardiac contractile bioenergetics through MICU1-dependent mechanisms.
bioRxiv · Sep 9, 2026 · PreprintBiochemistry