Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells
Alma‐Martina Cepika, Laura Amaya, Colin Waichler, Mansi Narula, Michelle M. Mantilla, Benjamin Craig Thomas, Pauline P. Chen, Robert Arthur Freeborn, Mara Pavel-Dinu, Jason Nideffer, Matthew Hebden Porteus, Rosa Bacchetta, Fabian Müller, William James Greenleaf, Howard Y. Chang, Maria Grazia Roncarolo
This study identifies the epigenetic signature and key transcription factors regulating human antigen-specific Tr1 cells, revealing their unique biology and potential for therapeutic applications.
Science Advances · Jul 10, 2026Peer-reviewedImmunology