Maria Grazia Roncarolo

This study identifies the epigenetic signature and key transcription factors regulating human antigen-specific Tr1 cells, revealing their unique biology and potential for therapeutic applications.

FOXP3-engineered regulatory T cells enhance intestinal barrier function in Crohn's disease enteroids via the PDGF-AA-PDGFR axis, independent of their immunosuppressive role.

The paper identifies CXCR6⁺ CD127⁻ Tr1 cells as key regulators in Plasmodium falciparum infection, showing they balance immunity and parasite persistence.

This study demonstrates that in utero hematopoietic stem cell transplantation (HSCT) without conditioning can effectively engraft donor cells in FA mouse models, achieving high donor chimerism and potentially offering a safe prenatal treatment for FA.

The paper develops an in vitro protocol to generate human Pharyngeal Endoderm cells and uses multi-omics analysis to reveal Retinoic Acid's role in their epigenetic and transcriptional development.

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.