Fabian Müller

methylTFR quantifies transcription factor activity from DNA methylation, identifying cell-type-specific regulators and resolving developmental trajectories in immune cells.

This study identifies the epigenetic signature and key transcription factors regulating human antigen-specific Tr1 cells, revealing their unique biology and potential for therapeutic applications.

This study identifies how genetic and environmental factors shape the human immune cell epigenome through differential methylation and chromatin accessibility changes.

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

The paper introduces InTAC-seq to quantify chromatin accessibility and transcription factor abundance in fixed cells, showing GATA1's role in erythroid lineage commitment.

GwEEP quantifies DNA modifying enzyme efficiencies using HPoxBS data, revealing dynamic changes in methylation and hydroxylation during cellular reprogramming and development.

The paper profiles midgestation human spinal cord cells at single-cell resolution, revealing early diversification of motor neurons and glial cell types.

The paper maps gene-regulatory dynamics in the developing human cerebral cortex using single-cell data, identifying key transcription factors and disrupted regulatory elements in ASD.

The paper maps stimulation-responsive chromatin changes in immune cells and identifies variants linked to autoimmunity.

The paper compares DNase I-Seq, ATAC-Seq, and NOMe-Seq to identify assay-specific features and their impact on chromatin accessibility and gene expression prediction.

The paper identifies partially methylated domains (PMDs) as widespread epigenomic features across human and mouse cells, showing cell-type specificity and links to gene expression, replication timing, and proliferation.

This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.